Demonstration of treatment planning software for hyperthermic intraperitoneal chemotherapy in a rat model

Background Hyperthermic intraperitoneal chemotherapy (HIPEC) is administered to treat residual microscopic disease after cytoreductive surgery (CRS). During HIPEC, fluid (41–43 °C) and drained through a limited number of catheters, risking thermal drug heterogeneities within the abdominal cavity that might reduce effectiveness. Treatment planning software provides unique tool for optimizing treatment delivery. This study aimed investigate influence treatment-specific parameters on homogeneity in peritoneal computed tomography based rat model.Method We developed computational dynamics (CFD) simulating dynamic flow, temperature distribution during oxaliplatin HIPEC. The location flow alternations rates were determined. was validated using data from experimental HIPEC studies.Results predicted core systemic concentration comparable values found literature. Adequate placement additional inflow catheters higher reduced spatial variation by −1.4 °C, −2.3 °C −1.2 respectively. Flow resulted temperatures (up +1.5 over surface. Higher also surface resulting more homogeneous effective dose.Conclusion presented insights which enables optimization an excellent basis human applications.